When using GENOTYPE_GIVEN_ALLELES with HaplotypeCaller, which uses EMIT_ALL_SITES and so has many calls where the entire cohort is nonvariant, do these reference only sites have to be filtered out before calling VQSR?
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When using GENOTYPE_GIVEN_ALLELES with HaplotypeCaller, which uses EMIT_ALL_SITES and so has many calls where the entire cohort is nonvariant, do these reference only sites have to be filtered out before calling VQSR?