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VQSR filter

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Hi,

I have exome sequencing data on 90 samples, and my lab uses the VQSR filter to remove low quality variants. I was wondering if I should also perform a genotype-level filter by DP/GQ post this VQSR filtering step. Is there a protocol that is recommended, or some metrics I can look at to determine if such a step is required?

Thanks,
Shweta


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